Figure 6.
Figure 6. CDKN3 is essential for centrosome maintenance. (A) Abnormal centrosome clusters in HeLaGFP-CENPA/GFP–γ-tub cells transfected with CDKN3 siRNA. Endogenous pericentrin was visualized by immunofluorescence. Arrows indicate multinucleated cells with supernumerary centrosomes. (B) Loss of CDKN3 causes generation of supernumerary centrosomes. P = 0.0073 in t test; n = 5.

CDKN3 is essential for centrosome maintenance. (A) Abnormal centrosome clusters in HeLaGFP-CENPA/GFP–γ-tub cells transfected with CDKN3 siRNA. Endogenous pericentrin was visualized by immunofluorescence. Arrows indicate multinucleated cells with supernumerary centrosomes. (B) Loss of CDKN3 causes generation of supernumerary centrosomes. P = 0.0073 in t test; n = 5.

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