Figure 9.
![Figure 9. Model for RIM-mediated synaptic vesicle priming. In WT terminals, vesicles (synaptic vesicle [SV]) that are close to the AZ (0) are first linked to the AZ (1) by one or few tethers (blue rods) in a RIM-dependent process. Likely by the action of RIM and MUNC13, vesicles progressively acquire additional shorter tethers, thereby reducing the distance between vesicle and AZ. Vesicles with multiple tethers are primed for release (2), and primed vesicles can fuse upon Ca2+ influx (3).](https://cdn.rupress.org/rup/content_public/journal/jcb/201/5/10.1083_jcb.201206063/5/jcb_201206063_fig9.jpeg?Expires=1771358119&Signature=INIQ1X9UxeOfnEWLCN8EQV3n1m9aP77HVD6szMn2SdgUPn02g83~ax1c~nn-WtCQCaNMeywraSyGWmNvMX2utIS81RCLCLVYwecUtuf-6ulWeaKxHqanClCXaqnSEmsKpd6r-HUIdvxv3NJWrOyFwPlUTNTBzUJ98F5QyHjH4LyiXIdTkGqLFRiGLFBXlsuluijX3i6XfVu~am1rQpULutjyUYNNvwu8K4sXzvZiMsbmX5L-GTSMVAPUfOGPqgiTwYOE4N7VIJH4IimIP0nly0D5j2HSvE1REXo0UqoVaFgDWSIXQRq8I~gX9c55Xg2PU7bh84Lvo6~qqpUDOh26RQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Model for RIM-mediated synaptic vesicle priming. In WT terminals, vesicles (synaptic vesicle [SV]) that are close to the AZ (0) are first linked to the AZ (1) by one or few tethers (blue rods) in a RIM-dependent process. Likely by the action of RIM and MUNC13, vesicles progressively acquire additional shorter tethers, thereby reducing the distance between vesicle and AZ. Vesicles with multiple tethers are primed for release (2), and primed vesicles can fuse upon Ca2+ influx (3).
