Figure 9.
Figure 9. EphA2 and MT1-MMP are coexpressed in invasive human breast carcinomas. (A) EphA2 and MT1-MMP immunohistochemistry of tumor-adjacent tissue, invasive breast carcinoma, and lymph node metastasis from the same patient. (B) Immunohistochemistry of invasive breast carcinomas and matched lymph node metastases. Arrows indicate junctional EphA2, and arrowheads indicate intracellular EphA2 in highly MT1-MMP–expressing tumor cells. Bars, 100 µm. (C) Quantitative analysis of the EphA2 and MT1-MMP staining (error bars indicate mean ± SEM). *, P = 0.05; **, P < 0.01; Mann–Whitney U test. (D and E) Scatter plot of EphA2 versus MT1-MMP staining (D; mean score), and of single-cell phenotype versus intracellular EphA2 (E; invasive carcinoma, n = 48; LN metastasis, n = 36). R, Pearson correlation coefficient; p-values were determined with a Student’s t test.

EphA2 and MT1-MMP are coexpressed in invasive human breast carcinomas. (A) EphA2 and MT1-MMP immunohistochemistry of tumor-adjacent tissue, invasive breast carcinoma, and lymph node metastasis from the same patient. (B) Immunohistochemistry of invasive breast carcinomas and matched lymph node metastases. Arrows indicate junctional EphA2, and arrowheads indicate intracellular EphA2 in highly MT1-MMP–expressing tumor cells. Bars, 100 µm. (C) Quantitative analysis of the EphA2 and MT1-MMP staining (error bars indicate mean ± SEM). *, P = 0.05; **, P < 0.01; Mann–Whitney U test. (D and E) Scatter plot of EphA2 versus MT1-MMP staining (D; mean score), and of single-cell phenotype versus intracellular EphA2 (E; invasive carcinoma, n = 48; LN metastasis, n = 36). R, Pearson correlation coefficient; p-values were determined with a Student’s t test.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal