Model of how N-WASP, MT1-MMP, and F-actin coordinate to function during cell invasion in 3D matrices. N-WASP localizes to and concentrates at the front of invading pseudopods, where it polymerizes F-actin (green) to form actin-rich hotspots that also contain cortactin and Arp2/3 complex. MT1-MMP (red) was delivered via LE/lysosomal trafficking to the plasma membrane, where it is captured and anchored by F-actin. MT1-MMP becomes enriched at degradation sites by interacting with actin patches.