LOBA in interphase cells of wt and Apc^mutant/+ mice. (A) LOBA is identified as a bent shape toward the crypt bottom in wt mice (see also Fig. 3 A). The numbers represent the cell numbering relative to the crypt bottom, where cell Nr 1 is located. (B–E) It is intact in two thirds (B) and lost in one third (C) of Apc^Δ14/+ crypts, in 80% of Apc^Min/+ crypts (D), and in all ACF of Apc^Δ14/+ mice (E). The dotted white lines define the region of interest drawn in the boxes to the right, linked by grey dotted lines. Bar, 5 µm.