Figure 8.
![Figure 8. Down-regulation of FGFR1 target genes by RNAi had an effect on cell migration. (A and B) Transwell migration assay showed that after 48-h RNAi treatment of KRTAP5-6, Stratifin (SFN), and PRSS27, MCF-7 cells migrated less compared with control cells (scrambled [Scr] RNAi treated). However, 48-h RNAi treatment of GRINA and EBI3 genes increased cell migration. *, P ≤ 0.05; **, P < 0.01; ***, P < 0.001 (paired Student’s t test). Error bars show means ± SEM. Ctr, control; KRT, keratin; PRS, PRSS27.](https://cdn.rupress.org/rup/content_public/journal/jcb/197/6/10.1083_jcb.201108077/7/jcb_201108077_fig8.jpeg?Expires=1771602305&Signature=2uO1zNpbPQbvJAYjH-Bv6MZdBXabwV0ar3SZYEDxNdr~jXcH2FlqK9mjwKJfD2DD7HwQa--PW3KkKuKZAmBiqlUy61Egzf1PtDam10qolBbY7nEpzBokxz44q1tfrmuQnOTSi6DYdMFi~YYJzscDJB5KczfMi6WB73AAcsaMiWh0P1cSmteN5djdTW44qko8r9iyVWn0u3t7iW~YjuMiDd0nAixqrBuFVjfE~jBnhRSxXEbMU1g90vicNfxG9kB4pYcbXf2QzUYfD4D8RuYDVVEiHKh3AgRA0r~pphAzS~N7vf1JaunDkWHFPW850X4P6o16iB-gig~mu5xvpj9USQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Down-regulation of FGFR1 target genes by RNAi had an effect on cell migration. (A and B) Transwell migration assay showed that after 48-h RNAi treatment of KRTAP5-6, Stratifin (SFN), and PRSS27, MCF-7 cells migrated less compared with control cells (scrambled [Scr] RNAi treated). However, 48-h RNAi treatment of GRINA and EBI3 genes increased cell migration. *, P ≤ 0.05; **, P < 0.01; ***, P < 0.001 (paired Student’s t test). Error bars show means ± SEM. Ctr, control; KRT, keratin; PRS, PRSS27.
