Shape shifting of the βA domain upon ligand binding. (A) Structural superposition of the MIDAS region of β1 before (blue) and after (yellow) the binding of ligand. (B) Structural superposition of the MIDAS region of β3 before (3FCS; green) and after (2VDR; red) the binding of ligand. In both A and B, α1 helix is colored darker than the rest of the molecule, and the structural differences between the ligand-free and RGD-bound forms (plot of distances between Cα atoms in each βA domain) are shown at the bottom. Locations of the α1 and α7 helices are denoted by black horizontal bars.