Integrative structure determination of the Nup84 complex. First, structural data are generated by experiments and computational methods. Second, the system is represented by mostly atomic structures of the subunits, and the data are translated into spatial restraints. Third, an ensemble of structures that satisfies the data is obtained by minimizing violations of the spatial restraints, starting from many different random configurations. Fourth, the ensemble is clustered into distinct sets of structures on the basis of similarities and analyzed in terms of geometry and accuracy.