Figure 9. Model of dEHBP1 function.... | Rockefeller University Press

Figure 9.

$Figure 9. Model of dEHBP1 function. Diagram adopted from Rajan et al. (2009), depicting a revised version of Delta recycling pathway. Neur-mediated endocytosis of Delta occurs at both the basal and the apical sides of the pIIb cell and results in the delivery of Delta to Rab5 early endosomes (Benhra et al., 2011). A fraction of Delta then follows a Rab11–Sec15-dependent route (Emery et al., 2005; Jafar-Nejad et al., 2005; Benhra et al., 2011) toward the ARS (Rajan et al., 2009). dEHBP1 (represented by red region overlapping the green region marking the ARS) is enriched at the actin-rich interface of the asymmetrically dividing pII cells where it may facilitate the localization of Delta via its interaction with Sec15 and Rab11. AP-2 and Numb inhibit the localization of Spdo at the plasma membrane of the pIIb cell (O’Connor-Giles and Skeath, 2003; Hutterer and Knoblich, 2005), while AP-1 inhibits the recycling of Spdo toward the apical portion of the pIIa cell (Benhra et al., 2010). Spdo depends on Sec15 activity to reach the plasma membrane (Tong et al., 2010).$

Model of dEHBP1 function. Diagram adopted from Rajan et al. (2009), depicting a revised version of Delta recycling pathway. Neur-mediated endocytosis of Delta occurs at both the basal and the apical sides of the pIIb cell and results in the delivery of Delta to Rab5 early endosomes (Benhra et al., 2011). A fraction of Delta then follows a Rab11–Sec15-dependent route (Emery et al., 2005; Jafar-Nejad et al., 2005; Benhra et al., 2011) toward the ARS (Rajan et al., 2009). dEHBP1 (represented by red region overlapping the green region marking the ARS) is enriched at the actin-rich interface of the asymmetrically dividing pII cells where it may facilitate the localization of Delta via its interaction with Sec15 and Rab11. AP-2 and Numb inhibit the localization of Spdo at the plasma membrane of the pIIb cell (O’Connor-Giles and Skeath, 2003; Hutterer and Knoblich, 2005), while AP-1 inhibits the recycling of Spdo toward the apical portion of the pIIa cell (Benhra et al., 2010). Spdo depends on Sec15 activity to reach the plasma membrane (Tong et al., 2010).