Model of Dsg2 and Dsc2 intracellular trafficking to the plasma membrane. Desmosomal cadherins exist in separate intracellular vesicular compartments that are transported using distinct motors. Dsg2-containing vesicles move inside the cell using the kinesin-1 motor protein, whereas kinesin-2, in cooperation with PKP2, is responsible for Dsc2 dynamic behavior. IF, intermediate filament.