Figure 2.
Figure 2. Rb and p130 have overlapping roles in the establishment of heterochromatin and H3K27me3 in differentiating cardiac myocytes. (A–C) Confocal microscopy was performed on myocardial sections from adult mice with the indicated genotypes (red, troponin C; green, indicated H3K9 or H3K27 modification; blue, DAPI). (A and B) Formation of H3K9me3-enriched heterochromatic foci was disrupted specifically in ACMs from CRbL/L;p130−/− mice. Panels e–h are enlarged images of the boxed areas in panels a–d. Bars, 5 µm. (C) H3K27me3 levels were dramatically decreased in CRbL/L;p130−/− myocardium compared with CRb+/+;p130+/+ myocardium. Bar, 25 µm.

Rb and p130 have overlapping roles in the establishment of heterochromatin and H3K27me3 in differentiating cardiac myocytes. (A–C) Confocal microscopy was performed on myocardial sections from adult mice with the indicated genotypes (red, troponin C; green, indicated H3K9 or H3K27 modification; blue, DAPI). (A and B) Formation of H3K9me3-enriched heterochromatic foci was disrupted specifically in ACMs from CRbL/L;p130−/− mice. Panels e–h are enlarged images of the boxed areas in panels a–d. Bars, 5 µm. (C) H3K27me3 levels were dramatically decreased in CRbL/L;p130−/− myocardium compared with CRb+/+;p130+/+ myocardium. Bar, 25 µm.

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