Model of caveolae disassembly and degradation of CAV1. Disassembly involves the release of cavin-1 from an intact caveola followed by dissociation of the destabilized 70S caveolar scaffold into 8S caveolar complexes. This may occur in EE after caveolar endocytosis or in the plasma membrane (PM), from where disassembled CAV1 is delivered to EE as endocytic cargo. Unassembled CAV1 may also arise when assembly of caveolar scaffolds in the Golgi is compromised and CAV1 arrives in the plasma membrane in the form of 8S complexes. In endosomes, the ubiquitinated 8S caveolar complexes are recognized by the ESCRT machinery and targeted to ILV facing the lumen. Upon lysis of ILV in LYS, CAV1 is exposed to the acidic vacuolar pH and degraded by proteolytic cleavage.