Figure 2.

Cell injury triggers Ca2+-dependent secretion of lysosomal ASM. ASM activity was assayed in the culture medium of NRK cells 4 min after exposure to SLO. An ∼10-fold increase in secreted ASM activity was observed after exposure to SLO/Ca2+. The data represent the mean ± SD of triplicate determinations. These results are representative of several independent experiments.

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