CD8/LDLRs prolong the lifetimes of productive CCPs. (A) TIR-FM time-lapse movies have been recorded and analyzed as described previously (Loerke et al., 2009). (A) Relative contributions and (B) lifetimes of CCP subpopulations labeled by LCa-EGFP are shown. Error bars represent cell-to-cell variation; the height of the lifetime bars in B denotes the range around the mean lifetime that contains 50% of the data. Brackets indicate confidence levels P < 10⁻⁸ (Kolmogorov-Smirnov test). The number of CCP trajectories (n) and cells (k) for each condition are: LCa-EGFP control (n = 100,823; k = 65); LCa-EGFP + CD8/LDLR (n = 70,955; k = 38); LCa-EGFP + ARH + CD8/LDLR (n = 23,394; k = 17).