Cross-correlations between all pairs of FA features, cell shape features, and cell coverage, in the significant “hits” of the siRNA screen. Spearman correlation values (see Materials and methods) between all pairs of measured features were calculated for all the screen hits (483 siRNAs). Correlation values are color-coded (see scale bar on the right), and the corresponding correlation (R) value is designated in each square. P-values of the correlations are indicated by the numbers in parentheses. The images shown exemplify significant correlations (P < 0.0005; marked by an asterisk), and refer to the square or squares enclosed by the red line, and connected with an arrow from the red dot. For example, the negative correlation between FA abundance and FA area, mean intensity, and length is indicated by the low abundance of big, bright, and long FAs in P101-PI3K, and high abundance of small, faint and short FAs in AMFR. An image of control (RF) cells is shown for comparison. The siRNAs are designated by the siRNA-targeted Entrez gene symbol. Perc., percentile. Bars, 10 µm.