Figure 6.
Figure 6. ILK regulates PKB/AKT phosphorylation. (A) AKT phosphorylation on Ser-473 is reduced in P1, P5, and P14 mutant nerves (n = 4, PP1 = 0.00088; n = 4, PP5 = 0.00090; n = 5, PP14 < 0.0001) unlike phosphorylation on Thr-308, which is higher in the mutants (n = 6; PP1 = 0.0018; PP5 = 0.0062; PP14 = 0.010). AKT total levels are slightly reduced in the mutants (n = 10, PP1 = 0.027; n = 10, PP5 = 0.010; n = 11, PP14 = 0.019). (B) GSK3β phosphorylation levels are not reduced in the absence of ILK either at P1 or P5. Error bars indicate ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

ILK regulates PKB/AKT phosphorylation. (A) AKT phosphorylation on Ser-473 is reduced in P1, P5, and P14 mutant nerves (n = 4, PP1 = 0.00088; n = 4, PP5 = 0.00090; n = 5, PP14 < 0.0001) unlike phosphorylation on Thr-308, which is higher in the mutants (n = 6; PP1 = 0.0018; PP5 = 0.0062; PP14 = 0.010). AKT total levels are slightly reduced in the mutants (n = 10, PP1 = 0.027; n = 10, PP5 = 0.010; n = 11, PP14 = 0.019). (B) GSK3β phosphorylation levels are not reduced in the absence of ILK either at P1 or P5. Error bars indicate ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

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