Defective endodermal cell distributions caused by cell cycle modulation lead to a secondary effect on neural induction. (A–F) At the bud stage, the narrowed expression of Otx2 and Sox2 caused by GemMO (B and E) was rescued by Snail1a (Sn1) mRNA (C and F). (G–J) Transplanted Casanova-overexpressing red donor cells containing ConMO (G and I) or GemMO (H and J) recover distributions of endodermal cells in the cas mutant acceptor embryo at both the 90% epiboly (G and H) and the 14 somite stages (I and J). The 14 somite stage embryos were viewed from the lateral with the dorsal side to the right. (K–N) At the bud stage, Otx2 (K and L) and Sox2 (M and N) are rescued in the cas mutant embryo with distributions of Casanova-expressing cells recovered, regardless of the donor embryo injected with ConMO (K and M) or GemMO (L and N). E, epiboly. Bar, 100 µm.