Cell cycle modulations lead to changes of apoptotic level during gastrulation. (A–H) Note that changes of the number of apoptotic cells detected by the TUNEL assay were reciprocally to those of the mitotically active cells. (I) The increased number of apoptotic cells caused by geminin mRNA was rescued by the coinjection of p53MO. (J) Knockdown of p65 led to an increased apoptosis. The shield stage embryos were viewed from the animal pole with the dorsal side to the right. Bar, 100 µm.