Figure 2.
Figure 2. 1D topography functionally mimics 3D fibrillar matrix. (A) Rapid migration of NIH-3T3 fibroblasts through a 3D cell-derived matrix. (B) Cytoskeletal alignment (green, actin) along oriented FN fibers (red). (C) Fibroblasts plated on single ∼1.5-µm lines mimic this 3D phenotype and migrate continuously. (D) Cell migration rates on 2D surfaces and 1D fibrillar lines at different FN ligand densities versus 3D cell-derived matrix. (E) HK migration over 2D, 3D matrix, and 1D fibrillar lines. (F) HK migration rates on substrates in E. Bars: (A, B, and E) 20 µm; and (C) 10 µm. *, P < 0.01 versus 2D; ‡, P < 0.05 versus 0.5 and 1,000 FN. Error bars indicate SEM.

1D topography functionally mimics 3D fibrillar matrix. (A) Rapid migration of NIH-3T3 fibroblasts through a 3D cell-derived matrix. (B) Cytoskeletal alignment (green, actin) along oriented FN fibers (red). (C) Fibroblasts plated on single ∼1.5-µm lines mimic this 3D phenotype and migrate continuously. (D) Cell migration rates on 2D surfaces and 1D fibrillar lines at different FN ligand densities versus 3D cell-derived matrix. (E) HK migration over 2D, 3D matrix, and 1D fibrillar lines. (F) HK migration rates on substrates in E. Bars: (A, B, and E) 20 µm; and (C) 10 µm. *, P < 0.01 versus 2D; ‡, P < 0.05 versus 0.5 and 1,000 FN. Error bars indicate SEM.

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