Figure 9.
Organization of Stt4 PIK patches at the PM. Ypp1 is a multivalent linker of Stt4 molecules ensuring the stability of the lipid kinase and the organization of the PIK patch. Efr3 anchors the Stt4–Ypp1 complex at the PM by binding Ypp1. TMD, transmembrane domain; LKUD, lipid kinase unique domain; PI4K, PtdIns 4-kinase domain.