The tail domain of the myosin IIA and IIB heavy chain isoforms dictates their role in adhesion dynamics. Time-lapse sequence of protruding regions of MIIA-deficient CHO.K1 cells expressing paxillin-mOrange together with GFP-MIIA/B (A) or GFP-MIIB/A (B). Bar, 5 μm. Note the formation of elongated adhesions within the protrusion in B, marked by arrowheads, whereas the equivalent region in A remains almost devoid of large adhesions.