Figure 5.
Figure 5. PS1 FAD mutation M146V accelerates cytosolic Ca2+ sequestration. (A) Traces show Ca2+-dependent fluorescence changes (ΔF/Fo) after 300-ms hyperpolarizing pulses to induce Ca2+ entry through nAChR expressed in the plasma membrane obtained from control and PS1 M146V expressing oocytes. (B) Table listing fast (T1) and slow (T2) time constants of double-exponential fits to the Ca2+ decay data.

PS1 FAD mutation M146V accelerates cytosolic Ca2+ sequestration. (A) Traces show Ca2+-dependent fluorescence changes (ΔF/Fo) after 300-ms hyperpolarizing pulses to induce Ca2+ entry through nAChR expressed in the plasma membrane obtained from control and PS1 M146V expressing oocytes. (B) Table listing fast (T1) and slow (T2) time constants of double-exponential fits to the Ca2+ decay data.

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