Tyr-1118 of Dock7 is essential for NRG1-induced migration of reaggregated Schwann cells. (A and B) pEGFP or pEGFP-siRNA–resistant wild-type Dock7 or Dock7Y1118F was cotransfected with control or Dock7-1 siRNA into Schwann cells. Cells were fixed with PFA, blocked, and stained with an anti-neurofilament antibody (red). The immunofluorescence images were merged. Bar, 100 μm. Error bars show ±SD. Data were evaluated by using one-way ANOVA (n = 16; *, P < 0.01; **, P < 0.015; ***, P < 0.02).