Analysis of zebrafish perlecan. (A) Schematic of human and zebrafish perlecan protein core. The roman numerals indicate the five domains. A key for the various modules is presented at the bottom. Arrows indicate the perlecan MO-DI, MO-DIII, and MO-DV morpholino targeting sites. See Fig. S1 for additional information . (B) Zebrafish perlecan is conserved syntenically. The zebrafish perlecan gene (hspg2) maintains a syntenic relationship with DDOST, PHC2, and SARS of mammalian species. Species and respective chromosome number are depicted; gene symbols are followed by the gene identification numbers from the National Center for Biotechnology Information Entrez Gene database, and distances between genes are displayed in megabases.