Morphology of receptor-mediated mitophagy revealed by CLEM (related to Fig. 1 A ). (A) Serial ultrathin sections of WT and DRP1 KO HeLa cells, with the grid and section numbers shown above each image. The framed images appear in Fig. 1 A. (B) CLEM (left) of another set of serial ultrathin sections of DRP1 KO HeLa cells showing co-localization of mito-mCherry (Mt-mChe, red) and GFP-LC3B (green). The boxed area is also displayed as single-color images for GFP-LC3B, Mt-mChe, and EM below the main image. Enlargements of the grid2 sec 3 EM image (also framed in the bottom panel) are shown in the middle and right panels. EM images of serial ultrathin sections are shown in the bottom row, with the grid and section numbers shown above each. Asterisks, ER; arrows, IM; mt, mitochondrion. Scale bars: 1 µm (CLEM) and 500 nm (EM).