Figure 9.
The role of EHBP-1, RAB-10, and LST-6 in facilitating post-Golgi exocytic trafficking. LST-6 acts as a GEF to enhance the functionality of RAB-10 during basolateral exocytosis, a role distinct from DENN-4, which serves as a GEF in basolateral recycling. EHBP-1, situated on recycling endosomes, captures RAB-10-positive post-Golgi exocytic carriers, facilitating the delivery of exocytic cargos to recycling endosomes. Ultimately, these cargos are transported to the plasma membrane, a process likely reliant on the functions of RME-1, LET-413, and the exocyst complex. Refer to the image caption for details.

The role of EHBP-1, RAB-10, and LST-6 in facilitating post-Golgi exocytic trafficking. LST-6 acts as a GEF to enhance the functionality of RAB-10 during basolateral exocytosis, a role distinct from DENN-4, which serves as a GEF in basolateral recycling. EHBP-1, situated on recycling endosomes, captures RAB-10-positive post-Golgi exocytic carriers, facilitating the delivery of exocytic cargos to recycling endosomes. Ultimately, these cargos are transported to the plasma membrane, a process likely reliant on the functions of RME-1, LET-413, and the exocyst complex.

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