Analyses of CD45-positive cells in CerS4-deficient mouse skin and differential gene experssion analyses in atopic dermatitis patient skin. (A) Representative images of P19, P21, and P58 Ctr and CerS4^epi−/− back skin sections stained for CD45 (grey) and keratin-14 (magenta). Scale bars 50 µm. (B) Differential gene expression of 20 patients diagnosed with AD. Positive values indicate genes that are upregulated in lesional skin and negative values indicate genes that are upregulated in non-lesional skin from Federico et al. (2020). NS = not significant; FC = fold change.