Figure 6.
Modulating actin dynamics alleviates dendrite branching abnormalities associated with KNL-1 loss. (A) Images of PVD dendrite organization at the L4 larval stage in the control and KNL-1 DEG animals upon acute 2-h treatment with either DMSO or 100 µM Lat-A. These images show both the anterior and posterior dendrites extending from the cell body within a 100 µm region. Scale bar, 10 µm. (B and C) Quantification of the PVD dendrite architecture by determining the number of 4° branches and overlaps between menorahs for the indicated conditions. n represents number of animals. Error bars represent mean ± 95% CI. P values from one-way ANOVA test followed by Tukey’s test (B) or Kruskal–Wallis test followed by Dunn’s test (C). (D) Images of PVD dendrite organization at the L4 larval stage in the control and KNL-1 DEG animals in combination with CYK-1 DEG or ARX-2 DEG as indicated. These images show both the anterior and posterior dendrites extending from the cell body within a 100 µm region. Scale bar, 10 µm. (E and F) Quantification of PVD dendrite architecture including number of 4° branches and overlaps between menorahs in indicated conditions. n represents number of animals. Error bars represent mean ± 95% CI. P values from one-way ANOVA test followed by Tukey’s test (E) or Kruskal–Wallis test followed by Dunn’s test (F).

Modulating actin dynamics alleviates dendrite branching abnormalities associated with KNL-1 loss. (A) Images of PVD dendrite organization at the L4 larval stage in the control and KNL-1 DEG animals upon acute 2-h treatment with either DMSO or 100 µM Lat-A. These images show both the anterior and posterior dendrites extending from the cell body within a 100 µm region. Scale bar, 10 µm. (B and C) Quantification of the PVD dendrite architecture by determining the number of 4° branches and overlaps between menorahs for the indicated conditions. n represents number of animals. Error bars represent mean ± 95% CI. P values from one-way ANOVA test followed by Tukey’s test (B) or Kruskal–Wallis test followed by Dunn’s test (C). (D) Images of PVD dendrite organization at the L4 larval stage in the control and KNL-1 DEG animals in combination with CYK-1 DEG or ARX-2 DEG as indicated. These images show both the anterior and posterior dendrites extending from the cell body within a 100 µm region. Scale bar, 10 µm. (E and F) Quantification of PVD dendrite architecture including number of 4° branches and overlaps between menorahs in indicated conditions. n represents number of animals. Error bars represent mean ± 95% CI. P values from one-way ANOVA test followed by Tukey’s test (E) or Kruskal–Wallis test followed by Dunn’s test (F).

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