Figure 2.
Abnormal detachment of RG occurs at early but not mid-corticogenesis. (A and B) Representative images and, Quantification of the distribution of GFP+Pax6+ cells in the VZ or outside the VZ between WT and Eml1 cKO brains 1 day post-IUE, at E13.5. (C and D) Representative images and Quantification of the distribution of GFP+Pax6+ cells in the VZ or outside the VZ between WT and Eml1 cKO brains 1 day post-IUE, at E15.5. Histograms show mean ± SEM. Boxes with dotted lines indicate the areas of higher magnification images displayed. Arrows indicate GFP+Pax6+ double positive cells. N = 5 for each condition from 3 to 4 litters. Test and significance: Two-way ANOVA, Sidak’s multiple comparison test. Data passed normality test. P value <0.0001 ****. Scale bars (A and C, equivalent for WT and cKO): 50 µm (for main and insets).

Abnormal detachment of RG occurs at early but not mid-corticogenesis. (A and B) Representative images and, Quantification of the distribution of GFP+Pax6+ cells in the VZ or outside the VZ between WT and Eml1 cKO brains 1 day post-IUE, at E13.5. (C and D) Representative images and Quantification of the distribution of GFP+Pax6+ cells in the VZ or outside the VZ between WT and Eml1 cKO brains 1 day post-IUE, at E15.5. Histograms show mean ± SEM. Boxes with dotted lines indicate the areas of higher magnification images displayed. Arrows indicate GFP+Pax6+ double positive cells. N = 5 for each condition from 3 to 4 litters. Test and significance: Two-way ANOVA, Sidak’s multiple comparison test. Data passed normality test. P value <0.0001 ****. Scale bars (A and C, equivalent for WT and cKO): 50 µm (for main and insets).

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