Figure 7.
Model for the coordinated action of the two F-actin modules to control the integration of fused secretory granules. After fusion the secretory granules undergo an expansion most likely due to a flow of membrane from the APM. The recruitment of the first actin-based module (composed of a mDia1-dependent F-actin/Tpm3.1 lattice) stabilizes the membranes counteracting the flow from the APM. *The stabilization of the granules is also facilitated by the recruitment of NMIIB as previously described (Milberg et al., 2017). This step is followed by the assembly of the NMIIA lattice (Milberg et al., 2017; Ebrahim and Weigert, 2019) and the second module composed of Arp2/3-dependent branched filaments that interact with the ERM protein Ezrin. Both the contractile activity of NMIIA and the expansion of the branch filaments generate the forces that drive the integration of the granules’ membrane.

Model for the coordinated action of the two F-actin modules to control the integration of fused secretory granules. After fusion the secretory granules undergo an expansion most likely due to a flow of membrane from the APM. The recruitment of the first actin-based module (composed of a mDia1-dependent F-actin/Tpm3.1 lattice) stabilizes the membranes counteracting the flow from the APM. *The stabilization of the granules is also facilitated by the recruitment of NMIIB as previously described (Milberg et al., 2017). This step is followed by the assembly of the NMIIA lattice (Milberg et al., 2017; Ebrahim and Weigert, 2019) and the second module composed of Arp2/3-dependent branched filaments that interact with the ERM protein Ezrin. Both the contractile activity of NMIIA and the expansion of the branch filaments generate the forces that drive the integration of the granules’ membrane.

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