Model of the regulation of autophagosome biogenesis by AMPK. Glucose withdrawal leads to AMPK activation, which promotes the recruitment of ATG13 to mobile ATG9 vesicles. Under these conditions, WIPI2 also accumulates on ATG9 vesicles, but their tethering to donor membranes to allow phagophore maturation is inhibited by AMPK activation. The exact molecular targets of AMPK that prevent phagophore tethering are unknown.