Impact of reduced detachment rates on untreated bipolar and CK666-treated monopolar dynamics. Bipolar dynamics were preserved with varied detachment rates of active Cdc42 and Scd1. (A) Bipolar dynamics after reducing the detachment rate of Cdc42 to 20% of the wild-type detachment rate. (B) Protein dynamics upon reducing the detachment rate of Scd1 to 20% of the wild-type rate. (C) The second parameter set effectively fits the untreated bipolar and CK666-treated monopolar data in Model 2. $δx=0.1,δc=0.07,δs=0.07$ for untreated, $δx=0.07,δc=0.07,δs=0.07$ for CK666-treated. (D) The third parameter set fits the untreated bipolar and CK666-treated monopolar in Model 2. $δx=1,δc=0.5,δs=0.3$ for untreated, $δx=0.6,δc=0.5,δs=0.3$ for CK666 condition.