A model of MAP1B functionality in TNBC cell. MAP1B, Tks5, and MT1-MMP are highly expressed in TNBC cells. MAP1B interacts with major invadopodia components cortactin and Tks5, in addition to microtubule and actin, to stabilize invadopodia. Additionally, MAP1B supports Tks5 association with microtubules. MAP1B depletion releases Tks5 from microtubules leading to degradation by basal autophagy, diminishing invadopodia and invasiveness of TNBC cells.