Figure 8.

Model for the proposed function of Svf1 in ceramide transport at the ER-Golgi interface. A model for vesicular and non-vesicular ceramide transport in yeast under normal growth conditions. Ceramides are transported by vesicular transport while Nvj2 resides in the NVJ. Under these conditions Svf1 transports ceramides in a non-vesicular pathway. Svf1 first picks up ceramide in the ER in a transient interaction with the organelle. Svf1 targets the cis-Golgi apparatus and releases ceramides that is than metabolized into cSPs.

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