Stabilization of perturbed or damaged MTs by CSPP1. Schematic model showing MT stabilizing activity of CSPP1. Growing MTs can acquire damages, creating access for CSPP1 to MT lumen, and CSPP1 potentially promotes MT lattice repair (left). Alternatively, an MT can undergo a growth perturbation (e.g., switch to a pre-catastrophe state), resulting in slow growth and/or altered tip structure. This promotes the binding of CSPP1 to microtubule lumen (right). First, a single CSPP1 molecule will bind, followed by additional CSPP1 molecules, causing a pause and increasing MT stability. Subsequently, the MT can resume rapid growth, while CSPP1 remains localized in the MT lumen.