Figure S4.
UFD1 and NPLOC4 influence the nuclear distribution of PML. U2OS PML−/− + YFP-PML cells were treated with NT siRNA or with siRNAs to the indicated p97 cofactors, exposed to arsenic and analyzed by time-lapse fluorescent imaging for 9.75 h. PML body parameters were plotted as a function of time (left panels; average—n = 10). In the right panels PML body parameters are compared in cells treated with NT siRNA or with siRNAs to the indicated p97 cofactors after 9.75 h arsenic treatment (average value ± SD). P values are two-tailed Student’s t test assuming similar data deviations comparing with NT + As. Each data point is a single field of view taken from the time course (n = 10). (A) Relative PML body area per cell. (B) Relative PML body number per cell. (C) Relative PML body size.

UFD1 and NPLOC4 influence the nuclear distribution of PML. U2OS PML−/− + YFP-PML cells were treated with NT siRNA or with siRNAs to the indicated p97 cofactors, exposed to arsenic and analyzed by time-lapse fluorescent imaging for 9.75 h. PML body parameters were plotted as a function of time (left panels; average—n = 10). In the right panels PML body parameters are compared in cells treated with NT siRNA or with siRNAs to the indicated p97 cofactors after 9.75 h arsenic treatment (average value ± SD). P values are two-tailed Student’s t test assuming similar data deviations comparing with NT + As. Each data point is a single field of view taken from the time course (n = 10). (A) Relative PML body area per cell. (B) Relative PML body number per cell. (C) Relative PML body size.

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