Top/bottom 1,000 pixel images of the local membrane environment surrounding the insulin receptor. A representative time-lapse data set of top/bottom 1,000-pixel images exhibiting biggest 1,000 pixels of ZNCC changes (red) and smallest 1,000 pixels of ZNCC (blue) in each ZNCC image. Arrowheads show areas of intense blebbing and membrane ruffling. Scale bar, 10 μm.