Examples of diverse clathrin coat structures. (A) Large clusters of clathrin molecules excluded from further analysis. Shown in top view (xy) with the dotted line indicating a 50 nm-thick z-slice (xz) shown below. (B) Vesicular structures are sometimes fitted with a lower θ than expected. (C) While a spherical model describes the structure of most endocytic clathrin coats faithfully, there are few cases, as exemplified here, where the elliptical and irregular shape of an assembling coat is difficult to approximate with a simple geometric model. Two orthogonal 50-nm-thick z-slices are shown here in xz and yz, and the respective spherical model fit is plotted as a dotted line. (D) Non-continuous labeling of clathrin manifests itself as holes in the coat, indicated with a blue arrow. All scale bars are 100 nm.