Figure S2. Statistics of CEs from 1,000... | Rockefeller University Press

Figure S2.

$Statistics of CEs from 1,000 randomization iterations for untreated and starved MCF10A WT, and KRASG12Vand PIK3CAH1047Rmutant cell lines. (A) Spaghetti plots of CEs identified in the original data from Fig. 3. (B) Spaghetti plots of CEs identified in a single iteration of randomization, where positions of binarized time series were shuffled according to Fig. S1 B. (C–E) Distributions of statistics calculated from 1,000 randomization iterations compared to the observed statistic indicated by the vertical dashed line: the number of CEs (C), the mean duration of CEs (D), the mean total number of unique cells in a CE, i.e., the “size” of a CE (E). The P value was calculated according to Eq. 1 as the fraction of cases when the statistic was at least as extreme as observed.$

Statistics of CEs from 1,000 randomization iterations for untreated and starved MCF10A WT, and KRAS ^G12V and PIK3CA ^H1047R mutant cell lines. (A) Spaghetti plots of CEs identified in the original data from Fig. 3. (B) Spaghetti plots of CEs identified in a single iteration of randomization, where positions of binarized time series were shuffled according to Fig. S1 B. (C–E) Distributions of statistics calculated from 1,000 randomization iterations compared to the observed statistic indicated by the vertical dashed line: the number of CEs (C), the mean duration of CEs (D), the mean total number of unique cells in a CE, i.e., the “size” of a CE (E). The P value was calculated according to Eq. 1 as the fraction of cases when the statistic was at least as extreme as observed.