BRD0705 targets the Glu196 residue of GSK3α. (A) Sequence alignment of the kinase domain of GSK3α and GSK3β. The hinge region was highlighted in green. Residues within 6 Å approximity of the ligands are marked with asterisk. (B and C) Molecular docking of GSK3α and BRD0705. Interaction between amino acid side chain and the inhibitor was annotated in C.