Figure 7.
Recruitment of NME by ICAP-1 to regulate cellular force by promoting inactive integrin internalization. Scheme representing the sequence of molecular events during clathrin-mediated integrin endocytosis occurring at the edge of FA. ICAP-1 acts as an adaptor protein in integrin endocytic process. ICAP-1 mediates cargo selection by positioning NME close to integrin (1), AP2, and dynamin (2) in order to fuel dynamin at the clathrin-coated pits (3) allowing execution of subsequent membrane deformation and vesicle fission (4) to ensure the turnover of integrins.