Figure 9.
Summary of Kap enrichment and compensation at the NPC permeability barrier. (A) Enrichment of Kapβ1 and CRM1 at the NPC under WT conditions based on their respective cellular abundances (CKap), apparent binding affinities (KD,Kap) to the FG Nups, and molecular volumes. (B) Depleting Kapβ1 significantly reduces its occupancy at the NPC, thereby allowing more CRM1 molecules to bind to the FG Nups. However, CRM1 compensation is constrained by its cellular concentration. (C) Depleting CRM1 does not elicit any detectable change to the permeability barrier due to (1) its low WT occupancy and (2) dominance of Kapβ1. Note that the size of CRM1 is larger than Kapβ1.

Summary of Kap enrichment and compensation at the NPC permeability barrier. (A) Enrichment of Kapβ1 and CRM1 at the NPC under WT conditions based on their respective cellular abundances (CKap), apparent binding affinities (KD,Kap) to the FG Nups, and molecular volumes. (B) Depleting Kapβ1 significantly reduces its occupancy at the NPC, thereby allowing more CRM1 molecules to bind to the FG Nups. However, CRM1 compensation is constrained by its cellular concentration. (C) Depleting CRM1 does not elicit any detectable change to the permeability barrier due to (1) its low WT occupancy and (2) dominance of Kapβ1. Note that the size of CRM1 is larger than Kapβ1.

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