Changes in the activator:inhibitor ratio produce a wide range of cortical behaviors. (A and A′) Modeling (A) and in vivo (A′) data of normalized Rho wave period over changing RGA-3/4^WT. Each dot represents a single oocyte; group mean ± 95% confidence interval; 0 ng/μl, n = 10; 66 ng/μl, n = 18; 166 ng/μl, n = 28; 333 ng/μl, n = 18; 1,000 ng/μl, n = 9; seven experiments. One-way ANOVA with Tukey post hoc test for multiple comparisons; data distribution was assumed to be normal but was not formally tested. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. (B) Representative oocytes from the quantifications shown in Fig. 7, C′ and D′, and Fig. S4 A′. Each row represents three individual cells at the noted RGA-3/4^WT. Waves progress from choppy/turbulent spirals to long unbroken spiral wave chains that dominate the cortex. Scale bar = 25 µm. Yellow asterisks represent double spiral cores.