Figure S5.
Schematic summary for ORP10-medated lipid countertransport and its role in retrograde membrane trafficking. PI4KIIα-mediated PI4P production at endosomes leads to MCS formation by ORP10, ORP9, and VAP. ORP10 mediates countertransport of PI4P and PS at the ER–endosome MCSs, which results in conversion of PI4P to PS at endosomes. A pool of PS then recruits EHD1, a dynamin-like ATPase, at endosomes, thereby promoting endosome fission during retrograde trafficking. See text for details.

Schematic summary for ORP10-medated lipid countertransport and its role in retrograde membrane trafficking. PI4KIIα-mediated PI4P production at endosomes leads to MCS formation by ORP10, ORP9, and VAP. ORP10 mediates countertransport of PI4P and PS at the ER–endosome MCSs, which results in conversion of PI4P to PS at endosomes. A pool of PS then recruits EHD1, a dynamin-like ATPase, at endosomes, thereby promoting endosome fission during retrograde trafficking. See text for details.

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