Figure S1.
VAMP4 KO mice exhibit hyperresponsiveness to glucose. (A) GTT results for male WT mice, homozygotic VAMP4 KO mice (Vamp4−/−), and heterozygotic VAMP4 KO mice (Vamp4+/−) at 14 wk of age (n = 6–7 mice per group); 2 g/kg glucose was used in the test. The asterisks indicate WT vs. KO. (B) The blood insulin levels in the GTT of male WT mice, homozygotic VAMP4 KO mice (Vamp4−/−), and heterozygotic VAMP4 KO mice (Vamp4+/−) at 14 wk of age were measured by ELISAs at 0, 15, and 30 min (n = 6–7 mice per group). The asterisks indicate WT vs. KO. (C) ITT results of male WT mice, homozygotic VAMP4 KO mice (Vamp4−/−), and heterozygotic VAMP4 KO mice (Vamp4+/−) at 16 wk of age (n = 6–7 mice per group); 0.5 U/kg insulin was used in the test. The data are presented as the mean ± SEM. *, P < 0.05. The statistical analyses were performed with two-tailed unpaired Student’s t test (A–C).

VAMP4 KO mice exhibit hyperresponsiveness to glucose. (A) GTT results for male WT mice, homozygotic VAMP4 KO mice (Vamp4−/−), and heterozygotic VAMP4 KO mice (Vamp4+/−) at 14 wk of age (n = 6–7 mice per group); 2 g/kg glucose was used in the test. The asterisks indicate WT vs. KO. (B) The blood insulin levels in the GTT of male WT mice, homozygotic VAMP4 KO mice (Vamp4−/−), and heterozygotic VAMP4 KO mice (Vamp4+/−) at 14 wk of age were measured by ELISAs at 0, 15, and 30 min (n = 6–7 mice per group). The asterisks indicate WT vs. KO. (C) ITT results of male WT mice, homozygotic VAMP4 KO mice (Vamp4−/−), and heterozygotic VAMP4 KO mice (Vamp4+/−) at 16 wk of age (n = 6–7 mice per group); 0.5 U/kg insulin was used in the test. The data are presented as the mean ± SEM. *, P < 0.05. The statistical analyses were performed with two-tailed unpaired Student’s t test (A–C).

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