Model of INAVA biology. ARNO and inhibitors of the Rho–ROCK pathway mediate INAVA localization at cellular junctions. In the cytosol, INAVA promotes IL-1β–TRAF6 inflammatory stress signaling and the muramyl dipeptide (MDP)–NOD2 pathway. Proteotoxic stress (ROS, inhibitors of HSP90 and the proteasome) induce cytosolic INAVA condensates containing the E3 ligase βTrCP2 and conjugated ubiquitin. Inhibitors of p38α, mTOR, and translation induce the resolution of stress-induced INAVA condensates. Ub, ubiquitin.