A small-molecule approach to delineate the biology of INAVA condensates. (A) Schematic (left panel) and results (middle panel) of screen for inducers of INAVA-GFP puncta. Ranked Z-scores are shown on the right panel; several highly ranked HSP90 inhibitors (red) or ROS inducers (blue) are indicated. Frequencies of distribution of negative controls are displayed to the right of graph. (B) Schematic (left panel) and results (middle panel) of screen for compounds that block IL-1β–induced puncta. Ranked Z-scores are shown on the right panel; a high proportion of top hits were MAPK p38α (red) and mTOR (blue) inhibitors. Frequencies of distribution of negative controls are displayed to the right of graph.