Model for TRIM37 function in ensuring accurate chromosome segregation and its relevance to mulibrey nanism. In the absence of TRIM37 activity, an ectopic centrobin-scaffolded condensate and centrin foci are formed. Approximately 25% of centrobin-scaffolded condensates assemble an ectopic spindle pole, resulting in both multipolar segregation and an elevated rate of lagging chromosomes. We propose that these low-frequency segregation errors caused by the centrobin-scaffolded ectopic spindle pole are major contributors to the pathology of mulibrey nanism. The centrin foci observed in TRIM37Δ cells are independent of the centrobin-scaffolded condensate; the functional impact of their formation remains to be elucidated.