Overview of clinical, demographic, pathological, and molecular information for the CRC patients of the NI240 phase III clinical trial. (A) Each column represents a patient and each row color codes a feature. Missing data are shown in white. CIC-derived features include estimates of absence (CIC = 0) or presence (CIC > 0) of CIC events from TMA sections prepared from tumor, invasive front, and normal tissue. Visualization was generated with the MATLAB package HCP. (B) Comparison between CIC events (median aggregated by patient, tissue, and staining marker) observed in TMA sections stained for H&E and c-MET. Marker color indicates tissue type. Marker size and transparency encode the number of cores. Solid black line and gray shaded area indicate the regression line and CI, respectively. Agreement between CIC estimates from H&E-stained and c-MET–stained TMA cores was computed using the Kendall τ correlation (Python package scipy). (C) CIC events (median and 95% CI) detected in TMA sections prepared from tumor center, invasive front, and matched normal tissue of colon or rectum. n_c and n_pt indicate number of tumor cores and patients, respectively. LVI, lymphovascular invasion.