Figure S3.
In utero injection method validated by silencing of GFP in GFP-expressing mice. (a) Schematic overview of in utero injection experiments. (b) Microscopy images showing the down-regulation of GFP signal in GFP-expressing mouse livers via in utero injection of LNP-siGFP in comparison to livers injected with control LNP-siLuc. Scale bar: 30 µm. (c) Immunofluorescence (IF) microscopy images of the livers injected with LNP-siRab35 and stained for HNF4a (yellow) and Sox9 (magenta). Scale bar: 30 µm.

In utero injection method validated by silencing of GFP in GFP-expressing mice. (a) Schematic overview of in utero injection experiments. (b) Microscopy images showing the down-regulation of GFP signal in GFP-expressing mouse livers via in utero injection of LNP-siGFP in comparison to livers injected with control LNP-siLuc. Scale bar: 30 µm. (c) Immunofluorescence (IF) microscopy images of the livers injected with LNP-siRab35 and stained for HNF4a (yellow) and Sox9 (magenta). Scale bar: 30 µm.

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